FDA Approved Bacitracin Powder For Sale CAS NO.1405-87-4

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Bacitracin Powder
bacitracin
Bacitracin Manufacturer

Quick Details

ProName: FDA Approved Bacitracin Powder For Sal...
CasNo: 1405-87-4
Appearance: white to off-white fluffy powder
Application: It is a white to off-white fluffy powd...
ProductionCapacity: Metric Ton/Day
Purity: 99%
Storage: room tem
LimitNum: 1 Kilogram
Valid Period: 36 months

Superiority

Why you should buy bacitracin from us

#1. High quality approval: Registered and approved by FDA

#2. GMP/DMF Available for foreign MOH registration

#3. High quality standards: Strictly meeting USP41 and EP6.0

#4. Quality Guarantee: Full refund for quality issues

#5. Sample for quality approval is available

Details

What is bacitracin

Cas number: 1405-87-4

Molecular formula: C66H102N17O16S

Molecular weight: 1421.68538

It is a white to off-white fluffy powder and one of our China GMP-Approved APIs along with Bacitracin zinc, polymyxin b sulfate. It is soluble in water, ethanol, and pyridine. Its acidic or neutral aqueous solution is relatively stable. When pH maintains at 5-7, its solution is stable for 4 weeks. When solution pH is greater than 9, bacitracin could degrade rapidly at room temperature.

First isolated in 1945 and later commercially produced, it is a mixture of related polypeptides widely used as an antibiotic in injections or topical formulations.

It is a mixture of related compounds with different antibacterial activities. Components include compound A, A1, B, B1, B2, C, D, E, F, G, and X. Compound A was found to have the most antibacterial activity. Compound B1 and B2 have similar potencies and are approximately 90% as active as compound A. Other components including F and X do not appear to be extensively studied.

It is manufactured by growing the bacteria Bacillus subtilis var Tracy in a container of liquid growth medium in our FDA-audited facility. After fermentation, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then we extract it from the medium through chemical processing.

it is an effective narrow-spectrum polypeptide with an antibacterial spectrum similar to penicillin and effective against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and actinomycetes. These polypeptides inhibit Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.

How is bacitracin produced

It is commercially manufactured by growing the bacteria Bacillus subtilis var Tracy I in a container of liquid growth medium. After a certain period, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then the antibiotic is extracted from the medium through chemical processes.

1. Fermentation: use Bacillus subtilis and B. licheniformis to get its solution. ( the solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).

2. Adjusting PH value: an alkaline solution is added to its solution to adjust the pH as 8 to 11, adjust pH as 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.

3. Extraction: it is then obtained by membrane separation, drying, pulverization, and sieving.
The spray-dried powder obtained by processing above can be used as pharmaceutical raw materials for medicine preparations such as injections and ontments with polmyxin b.

USP requires that the total content of compound A is no less than 40.0%, the total amount of A, B1. B2 and B3 should be greater than 70.0% and the potency is no less than 60IU/MG.

What can bacitracin be used for

It is used for human medicine as a polypeptide antibiotic against infections. Please note, it should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

It is primarily made into ointments as it is can cause kidney damage when it is taken orally.

It has been indicated in topical formulations for acute and chronic localized skin infections. It is also used intramuscularly for infantile streptococcal pneumonia and empyema. It is also formulated as an ointment with neomycin and polymyxin B as OTC.

Its ointment formulated with neomycin and polymyxin B along with hydrocortisone is indicated for the treatment of corticosteroid-responsive dermatoses with secondary infection.

It can also be used in pure form for those with allergies to the polymyxin B and neomycin components of the combination product.

It is also commonly used as an aftercare antibiotic on tattoos and circumcision. It is preferred over combination products such as Neosporin because of its fewer ingredients, which lowers the chances of an allergic reaction.

Although its allergic cross-reaction with sulfa drugs has been occasionally reported, bacitracin-containing topical preparations is a great alternative to silver sulfadiazine (Silvadene) for patients burnt with a sulfa allergy.

It has been used to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, it is used to distinguish S. pyogenes from other β-hemolytic streptococci.

It is also used to distinguish Haemophilus influenza colonies amongst respiratory flora; since H. influenza is intrinsically resistant to it, colonies would form within the zone of inhibition.